Mitochondria are involved in a number of cellular functions, which ensure that our cells, tissues and organs function efficiently and provide the individual with the necessary metabolic resources to undertake normal daily functions. It is becoming evident that mitochondrial dysfunction and mutation and abnormal regulation of the mitochondrial genome (mtDNA) can lead to an increasing number of severe metabolic disorders which are not only specific to single tissues or organs but also lead to multisystem disorders. Here, we analyse the role that mitochondria and mtDNA play in fertilisation and developmental outcome in order that we have a better understanding of how the efficient regulation of mitochondria and mtDNA during very early development ensure that an individual is born healthy and maintains a normal healthy lifestyle.
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- Introduction
Introduction
Related Sessions
- Introduction
- Mitochondrial structure
- Mitochondria as generators of cellular energy
- Other mitochondrial functions
- The mitochondrial genome
- Transcription and replication of the mitochondrial genome
- Inheritance of mtDNA
- The importance of transmitting one population of mtDNA
- The importance of mitochondria in the oocyte at the time of fertilisation
- The use of assisted reproductive technologies to overcome mitochondrial deficiency
- Mitochondria and mtDNA as biomarkers for oocyte and embryo development
- Conclusion
- References