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This section is supported by an unrestricted grant from OvaScience.

 

Introduction

The Virtual Academy of Egg Health discusses important topics on egg health. This dynamic section will be expanded with significant and timely IVF-related egg-health themes that are of interest to reproductive health professionals.

The role of mitochondria

In recent years, our understanding of mitochondria as the main source of energy has matured. It is well known that after fertilization, oocytes require a vast supply of energy, and are mainly dependent on the existing pool of mitochondria.
Mitochondrial dysfunction has been implicated in a number of pathophysiological processes, such as aging, neurodegenerative diseases, diabetes, obesity and infertility.

Mitochondrial supplementation in oocytes

Study results published until now have suggested that mitochondrial activity within oocytes may be supplemented by donor cytoplasmic transfer at the time of intracytoplasmic sperm injection (ICSI). These studies showed success; however, safety concerns arose due to the potential that two distinct populations of mitochondrial genomes would be present in the offspring.

Recently, the role of mitochondria has gained renewed attention due to the fact that autologous mitochondria can be extracted and injected into oocytes to increase their energy potential.

The objective of the mitochondria section

This IVF-Worldwide section was established to enable better understanding of the basic role and function of mitochondria in fertilized oocytes and in embryo development.
This section will contain basic science articles along with clinical experience reports. It will promote open discussion on the latest developments related to proposed treatments.

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